Tuberculosis Research Today is a free monthly online journal that collates and summarizes the latest research about Tuberculosis, including details on symptoms, causes, treatment, pulmonary, mycobacterium.

A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen.

Parra M, Cadieux N, Pickett T, Dheenadhayalan V, Brennan MJ

Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA.

Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.

Published 21 December 2005 in Infect Immun, 74(1): 786-9.
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