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Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy.

Breton G, Duval X, Estellat C, Poaletti X, Bonnet D, Mvondo Mvondo D, Longuet P, Leport C, Vildé JL

Department of Infectious and Tropical Diseases, INSERM E0357, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. guillaume.breton@bch.ap-hop-paris.fr

Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.

Published 3 December 2004 in Clin Infect Dis, 39(11): 1709-12.
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