Tuberculosis Research Today is a free monthly online journal that collates and summarizes the latest research about Tuberculosis, including details on symptoms, causes, treatment, pulmonary, mycobacterium.

Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the Study C randomized controlled trial.

Lienhardt C, Cook SV, Burgos M, Yorke-Edwards V, Rigouts L, Anyo G, Kim SJ, Jindani A, Enarson DA, Nunn AJ,

Clinical Trial Division, International Union Against Tuberculosis and Lung Disease, Paris, France. lienhardtc@who.int

Published 13 April 2011 in JAMA, 305(14): 1415-23.
Full-text of this article is available online (may require subscription).

Articles on Tuberculosis published 13 April 2011:

Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the Study C randomized controlled trial.   JAMA, 305(14): 1415-23.

[Abstract] [Full-text]

Articles on Tuberculosis published 17 March 2011:

Utility of reverse transcriptase PCR and DNA-PCR in the diagnosis of female genital tuberculosis.   J Med Microbiol, 60: 486-91.

This study was designed to test the utility of mRNA-based RT-PCR to detect viable bacilli, indicating active tubercular involvement, and DNA-PCR to detect present or past infection in the diagnosis of active female genital tuberculosis (TB) infection. A total of 200 subjects with complaints of infertility were enrolled in the study. Multiple sampling was done. One hundred and forty-three endometrial aspirate (EA), 94 peritoneal fluid/peritoneal washing (PF/PW) and six cornual biopsy (CB) ... [Abstract] [Full-text]

Articles on Tuberculosis published 15 March 2011:

Effects of antiretroviral therapy on immune function of HIV-infected adults with pulmonary tuberculosis and CD4+ >350 cells/mm3.   J Infect Dis, 203(7): 992-1001.

[Abstract] [Full-text]

Articles on Tuberculosis published 10 March 2011:

The social determinants of tuberculosis: from evidence to action.   Am J Public Health, 101(4): 654-62.

Growing consensus indicates that progress in tuberculosis control in the low- and middle-income world will require not only investment in strengthening tuberculosis control programs, diagnostics, and treatment but also action on the social determinants of tuberculosis. However, practical ideas for action are scarcer than is notional support for this idea. We developed a framework based on the recent World Health Organization Commission on Social Determinants of Health and on current ... [Abstract] [Full-text]

Articles on Tuberculosis published 2 March 2011:

ESAT-6- and CFP-10-specific Th1, Th22 and Th17 cells in tuberculous pleurisy may contribute to the local immune response against Mycobacterium tuberculosis infection.   Scand J Immunol, 73(4): 330-7.

Th1 cell-mediated adaptive immune response is very important but may not be sufficient to control Mycobacterium tuberculosis (M. tuberculosis) infection. The roles of the various T cell subsets and cytokines in the inflammatory processes are not clearly elucidated. We investigated whether Th1, Th22 and Th17 cells mediated cellular immunity at the local site of M. tuberculosis infection in patients with tuberculous pleurisy (TBP). The results showed that the cytokines IFN-γ and IL-22 but not ... [Abstract] [Full-text]

Exposure to Mycobacterium avium decreases the protective effect of the DNA vaccine pVAXhsp65 against Mycobacterium tuberculosis-induced inflammation of the pulmonary parenchyma.   Scand J Immunol, 73(4): 293-300.

This work investigated the effect of previous Mycobacterium avium exposure on the protective ability of the DNA vaccine pVAXhsp65 against inflammation in the pulmonary parenchyma. BALB/c mice were presensitized with heat-killed M. avium and then immunized with three doses of pVAXhsp65 prior to challenge with Mycobacterium tuberculosis. M. avium sensitization induced high levels of spontaneous IL-5 production that were concomitant with a positive delayed-type hypersensitivity reaction; ... [Abstract] [Full-text]

Articles on Tuberculosis published 1 March 2011:

Tuberculosis in patients receiving antiretroviral treatment: incidence, risk factors, and prevention strategies.   J Acquir Immune Defic Syndr, 56(4): 349-55.

[Abstract] [Full-text]

Tuberculosis in patients receiving antiretroviral treatment: incidence, risk factors, and prevention strategies.   J Acquir Immune Defic Syndr, 56(4): 349-55.

[Abstract] [Full-text]

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